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The inhibition of histone deacetylase, by promoting more transcriptionally active chromatin structures, likely presents the epigenetic mechanism for regulation of many of the neuroprotective effects attributed to valproic acid.
If you suddenly stop taking valproic acid, you may experience a severe, long-lasting and possibly life-threatening seizure.
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Abbott illegally marketed the drug for schizophrenia and agitated dementia, even though it was approved only for treatment of seizure disorders, or mania associated with bipolar disorder and migraines, according to a media release from the Justice Department.
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